# What do we know about the potential for repair of kinesins?

**URL:** <https://community.kif1a.org/t/what-do-we-know-about-the-potential-for-repair-of-kinesins/53>\
**Category:** Questions\
**Created:** [January 27, 2025, 4:07pm UTC](https://community.kif1a.org/t/what-do-we-know-about-the-potential-for-repair-of-kinesins/53 "2025-01-27T16:07:33Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![corylogan](https://yyz1.discourse-cdn.com/flex035/user_avatar/community.kif1a.org/corylogan/32/12_2.png) [@corylogan](https://community.kif1a.org/u/corylogan)\
**Post date:** [January 27, 2025, 4:07pm UTC](https://community.kif1a.org/t/what-do-we-know-about-the-potential-for-repair-of-kinesins/53/1 "2025-01-27T16:07:33Z")

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This article was recently shared with me, but it doesn’t say too much:

> **[KIF1A Gene Research Advances Rare Neurological Disorder Treatment](https://wewillcure.com/insights/rare-diseases/kif1a-gene-research-advances-rare-neurological-disorder-treatment)**
>
> Arne Gennerich, PhD, Professor of Biochemistry at the Albert Einstein College of Medicine and a 2022 XSeed Award winner, is racing to develop a treatment for patients with rare genetic neurological disorders known as KAND.

I think the most telling line is this:

> Our goal is to find a small molecule that improves the function of the mutant protein, helping it behave more like the wild-type. Ultimately, we’re aiming to restore near-normal function in the mutant.

What do we know about the potential of this approach, and the potential time this might take? I know you guys are aware of the research to some degree, as it looks like you had an interview with Arne back in 2022.

> **[From Structure to Therapeutics: Dr. Arne Gennerich Interview - KIF1A](https://www.kif1a.org/blog/from-structure-to-therapeutics-dr-arne-gennerich-interview/)**
>
> Ahead of our 2022 Virtual KAND Family & Scientific Engagement Conference on August 13, 2022, KIF1A.ORG interviewed core KIF1A Research Network members to discuss their #relentless efforts to understand KIF1A and help KAND patients in this special...

I guess I’m just wondering if there’s much progress and potential here.